Farag A, Taha M, Halim S
Department of Dermatology, Benha Faculty of Medicine, Egypt.
Br J Dermatol. 1994 Nov;131(5):684-6. doi: 10.1111/j.1365-2133.1994.tb04983.x.
The use of oral terbinafine in the treatment of superficial dermatophyte infections has been extensively studied, using different treatment regimens. To evaluate the efficacy of short-term therapy with oral terbinafine in cases of tinea cruris/corporis, 22 patients (21 male and one female) with mycologically proven tinea cruris/corporis, were included in the present study. Each patient received one tablet of terbinafine 250 mg daily for 1 week. Patients were followed-up for 6 weeks after completion of treatment. Clinical and mycological assessments were performed at the end of treatment, and at the end of the follow-up period. The mean sum of scores of signs and symptoms in all patients decreased significantly from 12.36 before treatment to 0 at the end of the follow-up period, and mycological investigations were negative in all patients at the end of the follow-up period. Our results show that 1-week therapy with oral terbinafine is highly effective in the treatment of tinea cruris/corporis.
口服特比萘芬治疗浅表皮肤癣菌感染已采用不同治疗方案进行了广泛研究。为评估口服特比萘芬短期治疗股癣/体癣的疗效，本研究纳入了22例经真菌学证实为股癣/体癣的患者（21例男性和1例女性）。每位患者每日服用1片250mg特比萘芬，持续1周。治疗结束后对患者进行6周的随访。在治疗结束时和随访期结束时进行临床和真菌学评估。所有患者体征和症状评分的平均总和从治疗前的12.36显著降至随访期结束时的0，并且在随访期结束时所有患者的真菌学检查均为阴性。我们的结果表明，口服特比萘芬1周疗法治疗股癣/体癣非常有效。
