Hanslik T M, Newman L, Tessman M, Morrissey A B, Friedlander M A
Department of Medical-Surgical Nursing, University Hospitals of Cleveland, Case-Western Reserve University, Ohio.
Adv Perit Dial. 1994;10:158-62.
Whether nasal carriage of Staphylococcus aureus is associated with an increased risk of S. aureus exit-site infection remains controversial. We performed nasal cultures prior to peritoneal dialysis catheter placement in all of our patients beginning in September 1990. We also performed nasal cultures on a cohort of patients already on peritoneal dialysis. Patients with positive cultures received a prescription for a ten-day course of intranasal mupirocin. Exit-site and nasal cultures were performed on every subsequent office visit until the end of the study in April 1993. The initial visit and three widely-spaced subsequent visits were chosen for data analysis. There were 68 patients entered into the study. Data from a total of 272 visits were analyzed. The patients ranged in age from 18-80 years. There were 27 diabetics. We found no correlation between initial positive nasal cultures and the subsequent development of a S. aureus exit-site infection. All identified nasal carriers were treated with mupirocin. However, the subsequent development of a S. aureus exit-site infection could not be correlated to a prior S. aureus carrier state or lack thereof.
金黄色葡萄球菌的鼻腔定植是否与金黄色葡萄球菌出口部位感染风险增加相关仍存在争议。自1990年9月起，我们对所有患者在置入腹膜透析导管前进行鼻腔培养。我们还对一组已接受腹膜透析的患者进行鼻腔培养。培养结果呈阳性的患者接受了为期十天的鼻内莫匹罗星治疗。在随后的每次门诊就诊时都进行出口部位和鼻腔培养，直至1993年4月研究结束。选择初次就诊以及三次间隔较远的后续就诊进行数据分析。共有68名患者进入该研究。总共分析了272次就诊的数据。患者年龄在18至80岁之间。有27名糖尿病患者。我们发现初次鼻腔培养阳性与随后发生金黄色葡萄球菌出口部位感染之间没有相关性。所有已识别的鼻腔定植菌携带者均接受了莫匹罗星治疗。然而，金黄色葡萄球菌出口部位感染的后续发生与先前是否为金黄色葡萄球菌定植菌状态无关。
