Sanmarco M, Bernard D
Laboratoire d'Immunologie, Faculté de Médecine, Marseille, France.
Autoimmunity. 1994;18(1):57-63. doi: 10.3109/08916939409014680.
IgG-class anticardiolipin antibodies (IgG-ACA) were found in 25% of patients with myasthenia gravis. The prevalence and the level distribution were significantly different from those of a normal donor population (p < 0.001). In myastenic patients, IgG-ACA bound negatively charged, but not zwitterionic, phospholipids. They were significantly associated with the thymic abnormalities, thymoma and thymic hyperplasia, but not with various factors such as age, sex, antinuclear antibodies, severity of the disease and clinical thrombosis. The IgG-ACA levels did not correlate with titers of anti-acetylcholine receptor antibodies. Thus in Myasthenia Gravis, asymptomatic IgG-ACA could reflect an immune dysregulation under the influence of thymic alterations.
在25%的重症肌无力患者中发现了IgG类抗心磷脂抗体（IgG-ACA）。其患病率和水平分布与正常供体人群显著不同（p<0.001）。在重症肌无力患者中，IgG-ACA与带负电荷的磷脂结合，但不与两性离子磷脂结合。它们与胸腺异常、胸腺瘤和胸腺增生显著相关，但与年龄、性别、抗核抗体、疾病严重程度和临床血栓形成等各种因素无关。IgG-ACA水平与抗乙酰胆碱受体抗体滴度无关。因此，在重症肌无力中，无症状的IgG-ACA可能反映了胸腺改变影响下的免疫失调。
