Gilbert M S, Forman R S, Moylan D S, Caruso F S
J Int Med Res. 1976;4(4):255-64. doi: 10.1177/030006057600400408.
A double-blind, randomized trial was conducted with 124 post-operative patients to compare the analgesic activity and possible side-effects of a new synthetic analgesic--butorphanol tartrate (1, 2, and 4 mg)--and pentazocine lactate (30 and 60 mg), adminstered intramuscularly. Butorphanol was determined to be 16 times more potent than pentazocine, on a weight basis. Both medications provided maximum pain relief within one hour after administration, and had comparable durations of action. Drowsiness was the most common side-effect, and it appeared to be dose related in all test groups.
对124名术后患者进行了一项双盲随机试验，以比较一种新型合成镇痛药——酒石酸布托啡诺（1毫克、2毫克和4毫克）和乳酸喷他佐辛（30毫克和60毫克）肌肉注射后的镇痛活性及可能的副作用。按重量计算，布托啡诺的效力被确定为喷他佐辛的16倍。两种药物在给药后一小时内均能提供最大程度的疼痛缓解，且作用持续时间相当。嗜睡是最常见的副作用，在所有测试组中似乎都与剂量有关。
