Parnes J R, Seong R H
Department of Medicine, Stanford University Medical Center, CA 94305-5487.
Semin Immunol. 1994 Aug;6(4):221-9. doi: 10.1006/smim.1994.1029.
The mechanism by which thymocytes expressing both the CD4 and CD8-coreceptor proteins differentiate into mature T cells expressing either CD4 or CD8 is not well understood. We have shown that expression of a chimeric CD8/CD4 transgene can alter T cell lineage commitment such that cells expressing a transgenic class I major histocompatibility complex-restricted T cell receptor can differentiate to the CD4 rather than those the CD8 lineage. The implications of these findings and those of others for existing instructive and stochastic models of thymocyte lineage commitment are discussed, and an alternative model is considered.
同时表达CD4和CD8共受体蛋白的胸腺细胞分化为仅表达CD4或CD8的成熟T细胞的机制尚未完全明确。我们已经表明，嵌合型CD8/CD4转基因的表达能够改变T细胞谱系定向，使得表达转基因I类主要组织相容性复合体限制性T细胞受体的细胞能够分化为CD4谱系而非CD8谱系。本文讨论了这些发现以及其他发现对现有的胸腺细胞谱系定向指导模型和随机模型的意义，并考虑了另一种模型。
