蛋白质热量营养不良和禁食对大鼠δ-氨基-γ-酮戊酸脱水酶和胆色素原脱氨酶活性的影响。

Influence of protein calorie malnutrition and fasting on the activities of delta-aminolevulinic acid dehydratase and porphobilinogen deaminase in rats.

作者信息

Adjarov D G, Naydenova E N, Kerimova M A, Pentieva K D, Ivanova L B, Ivanova A V

机构信息

Centre of Hygiene, Ecology and Nutrition, Sofia, Bulgaria.

出版信息

Exp Toxicol Pathol. 1994 Aug;46(3):199-202. doi: 10.1016/s0940-2993(11)80081-3.

DOI:10.1016/s0940-2993(11)80081-3

PMID:8000239

Abstract

Rats were fed a restricted standard diet (6-8 g daily) for 4 weeks. The erythrocyte activity of delta-aminolevulinic acid dehydratase showed a very expressed decrease (7.9 times) and its hepatic activity diminished more than twice. Porphobilinogen deaminase activity was reduced by 40% and 17% respectively. After a 3-day total food deprivation delta-aminolevulinic acid dehydratase activity remained unchanged in red blood cells, but an increase by 52% was found in the liver. The erythrocyte activity of porphobilinogen deaminase was reduced by 42% and its hepatic activity--by 16%.

摘要

给大鼠喂食限制标准饮食（每日6 - 8克），持续4周。δ-氨基-γ-酮戊酸脱水酶的红细胞活性显著降低（降低了7.9倍），其肝脏活性降低了两倍多。胆色素原脱氨酶活性分别降低了40%和17%。在完全禁食3天后，红细胞中的δ-氨基-γ-酮戊酸脱水酶活性保持不变，但肝脏中的该活性增加了52%。胆色素原脱氨酶的红细胞活性降低了42%，其肝脏活性降低了16%。