Feldmeier J J, Heimbach R D, Davolt D A, Brakora M J, Sheffield P J, Porter A T
Department of Radiation Oncology, Wayne State University, Detroit, Michigan.
Undersea Hyperb Med. 1994 Dec;21(4):467-75.
We reviewed all known published reports or studies related to a possible cancer-causing or growth-enhancing effect by hyperbaric oxygen. Published articles were retrieved using Medline searches for the period 1960-1993. Additional references were obtained from bibliographies included in those articles discovered in the computer search. Also, hyperbaric medicine text books and the published proceedings of international hyperbaric conferences were visually searched. Studies and reports discovered in this fashion and related to the topic were included in the review. Twenty-four references were found: 12 were clinical reports, 11 were animal studies, and 1 reported both an animal study and a clinical report. Three clinical reports suggested a positive cancer growth enhancement, whereas 10 clinical reports showed no cancer growth enhancement. Two animal studies suggested a positive cancer-enhancing effect, and 10 animal studies showed no such effect. (The report that included both animals and humans is counted in both groups). The vast majority of published reports show no cancer growth enhancement by HBO exposure. Those studies that do show growth enhancement are refuted by larger subsequent studies, are mixed studies, or are highly anecdotal. A review of published information fails to support a cancer-causing or growth-enhancing effect by HBO.
我们回顾了所有已知的已发表报告或研究，这些报告或研究涉及高压氧可能产生的致癌或促进生长的作用。通过检索1960年至1993年期间的医学在线数据库（Medline）获取已发表的文章。其他参考文献则从计算机检索中发现的文章所附的参考文献中获取。此外，还对高压医学教科书和国际高压氧会议的已发表会议记录进行了逐一查阅。以这种方式发现的与该主题相关的研究和报告都纳入了本次综述。共找到24篇参考文献：12篇为临床报告，11篇为动物研究，1篇既包含动物研究又包含临床报告。3篇临床报告提示有促进癌症生长的作用，而10篇临床报告未显示有促进癌症生长的作用。2篇动物研究提示有促进癌症生长的作用，10篇动物研究未显示有此作用。（既包含动物又包含人类的那篇报告在两组中都计算在内）。绝大多数已发表的报告显示，暴露于高压氧不会促进癌症生长。那些确实显示有促进生长作用的研究，被后续更大规模的研究所反驳，或者是混合研究类型，或者是高度轶事性的。对已发表信息的综述未能支持高压氧具有致癌或促进生长的作用。
