Dorfman H D, Czerniak B
Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, New York, New York.
Cancer. 1995 Jan 1;75(1 Suppl):203-10. doi: 10.1002/1097-0142(19950101)75:1+<203::aid-cncr2820751308>3.0.co;2-v.
Frequency distribution data for primary bone sarcomas have long been used to provide clues to the diagnosis of bone cancers after their identification in radiographs. Age and skeletal site are often helpful, in addition to specific radiographic features, in narrowing down the probable histologic categories of bone neoplasms before biopsy.
Data on 2627 histologically confirmed primary malignant tumors of bone, as collected by the SEER program during the period 1973-1987, were analyzed by age, sex, race, and anatomical site.
Osteosarcoma was the most frequently diagnosed primary sarcoma of bone (35.1%), followed by chondrosarcoma (25.8%), Ewing's sarcoma (16.0%), chordoma (8.4%), and malignant fibrous histiocytoma, including fibrosarcoma (5.6%). The most frequently diagnosed sarcoma of bone in persons younger than age 20 was osteosarcoma, followed by Ewing's sarcoma. Chondrosarcoma was the most frequently diagnosed bone tumor in the population older than age 50. The overall 5-year relative survival rates were as follows: osteosarcoma, 41.0%; chondrosarcoma, 72.7%; Ewing's sarcoma, 41.2%; chordoma, 63.8%; and malignant fibrous histiocytoma, 42.9%. There was an improvement in the survival rates during the period 1973-1987 for patients with chordoma and for white female patients with Ewing's sarcoma. Ewing's sarcoma and chordoma occurred almost exclusively in the white population.
SEER data provide a unique opportunity to evaluate the incidence and survival rates of bone sarcomas, which are uncommon but highly lethal tumors. The findings from this analysis provide information useful in the diagnosis of these cancers.
原发性骨肉瘤的频率分布数据长期以来一直用于在X线片中识别骨癌后为其诊断提供线索。除了特定的X线特征外，年龄和骨骼部位通常有助于在活检前缩小骨肿瘤可能的组织学类型范围。
对监测、流行病学与最终结果（SEER）计划在1973年至1987年期间收集的2627例经组织学确诊的原发性骨恶性肿瘤数据，按年龄、性别、种族和解剖部位进行分析。
骨肉瘤是最常诊断出的原发性骨肉瘤（35.1%），其次是软骨肉瘤（25.8%）、尤因肉瘤（16.0%）、脊索瘤（8.4%）以及恶性纤维组织细胞瘤，包括纤维肉瘤（5.6%）。20岁以下人群中最常诊断出的骨肉瘤是骨肉瘤，其次是尤因肉瘤。软骨肉瘤是50岁以上人群中最常诊断出的骨肿瘤。总体5年相对生存率如下：骨肉瘤，41.0%；软骨肉瘤，72.7%；尤因肉瘤，41.2%；脊索瘤，63.8%；恶性纤维组织细胞瘤，42.9%。1973年至1987年期间，脊索瘤患者以及白人女性尤因肉瘤患者的生存率有所提高。尤因肉瘤和脊索瘤几乎仅发生在白人人群中。
SEER数据提供了一个独特的机会来评估骨肉瘤的发病率和生存率，骨肉瘤是罕见但极具致命性的肿瘤。该分析结果为这些癌症的诊断提供了有用信息。
