Drury I, Beydoun A, Garofalo E A, Henry T R
EEG Laboratory, University of Michigan Medical School, Ann Arbor.
Epilepsia. 1995 Jan;36(1):41-7. doi: 10.1111/j.1528-1157.1995.tb01663.x.
Twenty-six children (16 boys and 10 girls) with hypsarrhythmia and infantile spasms (IS) were studied at the University of Michigan EEG Laboratory in a 4-year period. Six (2 boys, 4 girls), had asymmetric hypsarrhythmia with a preponderance of both slowing and epileptiform activity over one hemisphere. All 6 had the symptomatic form of IS, 4 with dysplastic conditions, 1 with porencephaly from a cerebral infarct, and 1 with hypoxicischemic encephalopathy. Five children had focal abnormalities on either physical examination or imaging studies. Four had the highest amplitude slowing and most epileptiform activity ipsilateral to the lesion, in 1, it was contralateral. Asymmetric hypsarrhythmia constituted 23% of cases with hypsarrhythmia examined at our EEG laboratory. The significant success in surgical therapy for some children with IS indicates the importance of identifying focal hemispheric abnormalities even if they are not apparent clinically. EEG may suggest focal changes not detected clinically or radiologically.
在四年时间里，密歇根大学脑电图实验室对26名患有高峰失律和婴儿痉挛症（IS）的儿童（16名男孩和10名女孩）进行了研究。其中6名（2名男孩，4名女孩）患有不对称高峰失律，一个半球的慢波活动和癫痫样活动均占优势。这6名儿童均患有症状性IS，4名患有发育异常，1名因脑梗死导致孔洞脑，1名患有缺氧缺血性脑病。5名儿童在体格检查或影像学检查中发现有局灶性异常。4名儿童病变同侧出现最高波幅的慢波和最明显的癫痫样活动，1名儿童则出现在对侧。不对称高峰失律占我们脑电图实验室检查的高峰失律病例的23%。一些患有IS的儿童手术治疗取得显著成功，这表明即使局灶性半球异常在临床上不明显，识别它们也很重要。脑电图可能提示临床上或放射学上未检测到的局灶性变化。
