Catteau D, Barthélémy C, Deveaux M, Robert H, Trublin F, Marchandise X, Van Drunen H
Laboratoire de Pharmacie Galénique et Biopharmacie, Faculté de Pharmacie, Lille, France.
Eur J Drug Metab Pharmacokinet. 1994 Apr-Jun;19(2):91-8. doi: 10.1007/BF03188829.
The aim of this work was to use radiopharmaceuticals such as technetium (99mTc) and indium (DTPA-Ca111In) to visualize, with a gamma-camera, the disintegration area and time of 3 types of enteric coated hard gelatin capsules (obtained by 3 different preparation processes) and thus, to verify that they are really resistant in gastric fluids and soluble in intestinal zones. Results are well correlated with those previously obtained in vitro (disintegration, dissolution) and in vivo (profiles of plasmatic concentrations versus time).
这项工作的目的是使用放射性药物，如锝（99mTc）和铟（DTPA-Ca111In），通过伽马相机来观察3种肠溶硬明胶胶囊（通过3种不同制备工艺获得）的崩解区域和时间，从而验证它们在胃液中确实具有抗性，并在肠道区域可溶解。结果与先前在体外（崩解、溶解）和体内（血浆浓度与时间的曲线）获得的结果高度相关。
