Wieser H G
Department of Neurology, University Hospital, Zürich, Switzerland.
Eur Neurol. 1994;34 Suppl 1:58-62. doi: 10.1159/000119511.
Positron emission tomography (PET) measures regional cerebral metabolism and blood flow. PET imaging has been quite successful in identifying focal epileptogenesis as an area of hypometabolism between attacks. PET has proven to be an important diagnostic tool in selecting patients with partial epilepsy, in particular with foci in the temporal lobe, for resective surgery. Because of the high costs and complexities of PET, this technology has been confined to a limited number of centers. Single photon emission computed tomography (SPECT) can also be used for noninvasive functional imaging of the brain because it demonstrates regional cerebral blood flow which is linked to cerebral metabolism. SPECT uses conventional and readily available equipment and radiopharmaceuticals. Emphasizing the outstanding UCLA experience with PET, the presently available data on the usefulness of these functional imaging techniques in the context of surgical treatment of the epilepsies are reviewed.
正电子发射断层扫描（PET）可测量局部脑代谢和血流情况。PET成像在识别发作间期低代谢区域的局灶性癫痫起源方面颇为成功。PET已被证明是选择部分性癫痫患者，尤其是颞叶有病灶的患者进行切除性手术的重要诊断工具。由于PET成本高昂且操作复杂，这项技术仅在少数中心应用。单光子发射计算机断层扫描（SPECT）也可用于脑部无创功能成像，因为它能显示与脑代谢相关的局部脑血流情况。SPECT使用的是常规且易得的设备和放射性药物。本文回顾了加利福尼亚大学洛杉矶分校在PET方面的卓越经验，以及目前关于这些功能成像技术在癫痫外科治疗中的有用性的数据。
