Ernst W H, Janknecht R, Cahill M A, Nordheim A
Institut für Molekularbiologie, Medizinische Hochschule Hannover, Germany.
FEBS Lett. 1995 Jan 2;357(1):45-9. doi: 10.1016/0014-5793(94)01321-q.
The serum response element (SRE) contributes to transcriptional repression of the c-fos proto-oncogene. We show that the transcription factor SRF is able to repress SRE-dependent transcription, apparently by sequestering a co-activator. Only the DNA-binding core region is required for this SRE-dependent repression. Furthermore the phosphorylation status at potential casein kinase II sites within an N-terminal repression domain affects SRE-independent transcription. SRF may thus pleiotropically influence cellular transcription, representing a novel aspect of SRF function.
血清反应元件（SRE）有助于c-fos原癌基因的转录抑制。我们发现转录因子SRF能够抑制依赖SRE的转录，显然是通过隔离一种共激活因子来实现的。这种依赖SRE的抑制只需要DNA结合核心区域。此外，N端抑制域内潜在的酪蛋白激酶II位点的磷酸化状态会影响不依赖SRE的转录。因此，SRF可能对细胞转录产生多效性影响，这代表了SRF功能的一个新方面。
