Requero M A, González M, Goñi F M, Alonso A, Fidelio G
Departamento de Bioquímica, Universidad del País Vasco, Bilbao, Spain.
FEBS Lett. 1995 Jan 2;357(1):75-8. doi: 10.1016/0014-5793(94)01326-v.
The ability of fatty acyl-CoA's and fatty acylcarnitines to penetrate phospholipid monolayers was comparatively studied, in view of the important role of both kinds of derivatives in fatty acid transport across mitochondrial membranes. The interaction occurs predominantly through hydrophobic forces. Acylcarnitines penetrate phospholipid monolayers more strongly than acyl-CoAs; in addition the former show a positive cooperativity when they bind to the interface. These properties would facilitate membrane transfer of fatty acylcarnitines over that of their CoA homologues.
鉴于这两种衍生物在脂肪酸跨线粒体膜转运中都发挥着重要作用，对脂肪酰辅酶A和脂肪酰肉碱穿透磷脂单分子层的能力进行了比较研究。这种相互作用主要通过疏水作用力发生。脂肪酰肉碱比脂肪酰辅酶A更强烈地穿透磷脂单分子层；此外，前者在与界面结合时表现出正协同性。这些特性将促进脂肪酰肉碱比其辅酶A同系物更易进行膜转运。
