Balasubramaniam V, Appasamy P M
Pittsburgh Cancer Institute and School of Medicine, University of Pittsburgh, PA.
Dev Comp Immunol. 1994 May-Jun;18(3):179-91. doi: 10.1016/0145-305x(94)90010-8.
Murine T cells bearing the gamma delta T-cell receptor (gamma delta TCR) are the major lymphocyte subset in the thymus early in fetal development, and postnatally they are the major population of T cells in the epithelia of nonlymphoid tissues including the intestine, skin, tongue, lung, and reproductive organs. The site of origin of gamma delta T-cell precursors (pre-T cells) changes during fetal development, reflecting the sites of active hematopoiesis. In addition, the pattern of expression of specific gamma delta TCR variable (V) region genes changes during fetal and neonatal development, and is unique in different epithelial tissues postnatally. We herein review the literature describing these developmental changes and provide a model for the developmental pathways of murine gamma delta T cells.
携带γδ T细胞受体（γδ TCR）的小鼠T细胞是胎儿发育早期胸腺中的主要淋巴细胞亚群，出生后它们是非淋巴组织上皮中T细胞的主要群体，这些非淋巴组织包括肠道、皮肤、舌头、肺和生殖器官。γδ T细胞前体（前T细胞）的起源部位在胎儿发育过程中会发生变化，这反映了活跃造血的部位。此外，特定γδ TCR可变（V）区基因的表达模式在胎儿和新生儿发育过程中会发生变化，并且在出生后不同的上皮组织中是独特的。我们在此回顾描述这些发育变化的文献，并为小鼠γδ T细胞的发育途径提供一个模型。
