Brenner B, Back D, Ben-Porath E, Hazani A, Martinowitz U, Tatarsky I
Hematology Institute, Rambam Medical Center, Haifa, Israel.
Isr J Med Sci. 1994 Dec;30(12):886-90.
The prevalence, clinical manifestations and serological markers of hepatitis C virus (HCV), hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections were studied in 112 multiply transfused patients (49 hemophiliacs receiving either nonheat-treated factor concentrates or cryoprecipitate, 33 thalassemic, 20 refractory anemia and 10 leukemia patients). Positive serological markers for HCV, HBV and HIV were found to correlate with number of donors and duration of disease (logistic regression P = 0.0001 and 0.01 respectively). Viral infectivity was significantly correlated with type of blood product. HCV seropositivity was more common in hemophiliacs treated with nonheat-treated factor concentrates (93%) compared to those receiving cryoprecipitate (37%) or nonhemophiliacs receiving red packed cells (20%) (P < 0.001). Likewise, HBV seropositivity in patients receiving the above blood products was 83%, 61% and 26% respectively (P < 0.001), and HIV seropositivity was 35%, 6% and 0% respectively (P < 0.001). Acute or chronic liver disease was documented in 4 of 14 (28%) HCV-positive patients. Increased liver enzymes were recorded in sera of 43% HCV-positive patients and 18% HBV-positive patients compared to 22% of HBV and 20% HCV-seronegative patients (P = 0.076). Of 47 HCV-positive patients 24 were coinfected by HBV and 9 had triple infection (HCV, HBV and HIV). No solitary HIV infection was found. HIV seropositivity was always accompanied by serologic evidence for HBV with or without HCV infection.
对112例多次输血患者（49例接受非热处理因子浓缩物或冷沉淀的血友病患者、33例地中海贫血患者、20例难治性贫血患者和10例白血病患者）进行了丙型肝炎病毒（HCV）、乙型肝炎病毒（HBV）和人类免疫缺陷病毒（HIV）感染的患病率、临床表现及血清学标志物研究。发现HCV、HBV和HIV的阳性血清学标志物与供血者数量和病程相关（逻辑回归分析P值分别为0.0001和0.01）。病毒感染性与血液制品类型显著相关。与接受冷沉淀的血友病患者（37%）或接受红细胞悬液的非血友病患者（20%）相比，接受非热处理因子浓缩物治疗的血友病患者中HCV血清阳性更为常见（93%）（P<0.001）。同样，接受上述血液制品的患者中HBV血清阳性率分别为83%、61%和26%（P<0.001），HIV血清阳性率分别为35%、6%和0%（P<0.001）。14例HCV阳性患者中有4例（28%）记录有急性或慢性肝病。与HBV和HCV血清阴性患者分别为22%和20%相比，43%的HCV阳性患者和18%的HBV阳性患者血清中肝酶升高（P=0.076）。47例HCV阳性患者中，24例合并HBV感染，9例为三重感染（HCV、HBV和HIV）。未发现单纯HIV感染。HIV血清阳性总是伴有HBV感染的血清学证据，无论是否合并HCV感染。
