Abbot N C, Beck J S, Carnochan F M, Gibbs J H, Harrison D K, James P B, Lowe J G
Pathology Department, University of Dundee, United Kingdom.
J Appl Physiol (1985). 1994 Aug;77(2):767-73. doi: 10.1152/jappl.1994.77.2.767.
Transcutaneous PO2 and PCO2 measurements and estimates of skin respiration were monitored at different levels of inspired PO2 in 20 healthy adults during the first 4 days of the tuberculin reaction, a convenient model of acute inflammation. Hyperoxia at 1 and 2 ATA significantly increased transcutaneous PO2 levels in undisturbed and in inflamed skin but did not fully correct the relative hypoxia at the site of inflammation. Hypercapnia was reduced with O2 breathing at 2 ATA. The apparent rate of O2 consumption at the reaction site was raised during hyperoxia, most prominently at 2 ATA. The most intense reactions showed a central relative slowing of laser-Doppler blood flow indicative of microcirculatory impairment. The extent of the relative hypoxia and hypercapnia was greatest in these strongest reactions. The density of lymphocytes and monocytes in biopsies of 48-h reactions was loosely related to the corresponding transcutaneous PO2 measurements. The present study provides evidence that diffusion barriers, in addition to increased local respiration, can contribute to the apparent hypoxia and hypercapnia of this inflammatory model.
在结核菌素反应（一种方便的急性炎症模型）的前4天，对20名健康成年人在不同吸入氧分压水平下的经皮氧分压和二氧化碳分压测量以及皮肤呼吸估计值进行了监测。1个和2个绝对大气压下的高氧显著提高了未受干扰皮肤和发炎皮肤的经皮氧分压水平，但并未完全纠正炎症部位的相对缺氧。在2个绝对大气压下吸氧可降低高碳酸血症。在高氧期间，反应部位的表观耗氧率升高，在2个绝对大气压下最为显著。最强烈的反应表现为激光多普勒血流在中心相对减慢，表明微循环受损。在这些最强的反应中，相对缺氧和高碳酸血症的程度最大。48小时反应活检中淋巴细胞和单核细胞的密度与相应的经皮氧分压测量值存在松散的相关性。本研究提供了证据，表明除了局部呼吸增加外，扩散障碍也可能导致这种炎症模型中明显的缺氧和高碳酸血症。
