Ishida R, Andoh T
Laboratory of Biochemistry, Aichi Cancer Center Research Institute.
Gan To Kagaku Ryoho. 1994 Jun;21(7):952-61.
Altered DNA topoisomerase I and II have been shown in many cell lines resistant to topoisomerase inhibitors, showing that topoisomerases are main molecular targets of these inhibitors. In this paper, recent studies on the mechanism of resistance to DNA topoisomerase I and II inhibitors are reviewed.
在许多对拓扑异构酶抑制剂耐药的细胞系中已发现DNA拓扑异构酶I和II发生改变，这表明拓扑异构酶是这些抑制剂的主要分子靶点。本文对DNA拓扑异构酶I和II抑制剂耐药机制的最新研究进行了综述。
