Todd G, Saxe N
Department of Dermatology, Groote Schuur Hospital, Cape Town, Republic of South Africa.
Arch Dermatol. 1994 Jun;130(6):759-62.
The acro-osteolytic diseases are a heterogeneous group of bone disorders characterized by bone resorption. Acquired and genetic forms have been well described. As hand abnormalities are frequently encountered in dermatologic practice, bone resorptive states, with particular reference to the idiopathic osteolytic disorders, are discussed.
Asymptomatic terminal phalangeal osteolysis has been investigated in two unrelated young adults with no other bony or systemic abnormalities. The nails of the attenuated bulbous fingers were dystrophic, and pigmentary changes were present in the affected areas. The skin was otherwise normal, and there was minimal soft-tissue loss. Roentgenograms of the hands and feet showed varying stages of phalangeal osteolysis.
Both cases represent primary idiopathic acro-osteolysis, as the bony changes are limited to the distal phalanges of the hands and feet. There were no features in the history or clinical evaluation to support a diagnosis of secondary acro-osteolysis.
肢端骨质溶解症是一组以骨质吸收为特征的异质性骨病。已对获得性和遗传性形式进行了充分描述。由于手部异常在皮肤科实践中经常遇到，本文讨论了骨质吸收状态，特别是特发性骨质溶解症。
对两名无其他骨骼或全身异常的无关年轻成年人进行了无症状末节指骨骨质溶解的研究。变细的球根状手指的指甲营养不良，受累区域出现色素沉着变化。皮肤其他方面正常，软组织损失最小。手足X线片显示指骨骨质溶解的不同阶段。
两例均代表原发性特发性肢端骨质溶解症，因为骨骼变化仅限于手足的远端指骨。病史或临床评估中没有特征支持继发性肢端骨质溶解症的诊断。
