Synthesis and anticonvulsant activity of new 1-substituted 1'-methyl-3-chloro-2-oxospiro (azetidin-3',4-indol-2' ones).

The aim of the present research work is to discover new compounds with potential anticonvulsant activity. Several indolinone derivatives and also azetidinones are reported to have significantly anticonvulsant activity. So, it was thought considerable to synthesise compounds having both these moieties and study their anticonvulsant activity. The new spiroazetinones synthesized from the reaction of 3-(N-substituted) imino-1-methyl-indol-2-ones with chloroacetyl chloride in presence of triethylamine have been characterised on the basis of triethylamine have been characterised on the basis of satisfactory analytical and spectral data. Of the eight compounds screened in the series two compounds (3c and 3h) exhibited significant activity against MES.