Boddi W, Nozzoli C, Francois C, Amorosi A, Grifoni S, Morettini A, Olivotto J, Berni G
U.O. Medicina III, Policlinico di Careggi, Firenze.
Ann Ital Med Int. 1994 Jan-Mar;9(1):32-4.
Parathyroid gland carcinoma is a rare cause of primary hyperparathyroidism. The authors discuss the case of a 56-year-old man who presented with hypercalcemia and multiple bone lesions suggestive of tumor metastases. Laboratory and radiological investigations revealed primary hyperparathyroidism in a patient with evidence of osteitis fibrosa cystica, sustained by carcinoma of a mediastinal parathyroid gland. Early titration of parathyroid hormone (PTH) levels in all patients with hypercalcemia of unclear cause is important for early diagnosis of cases that are tumor-sustained and prevention of the most severe complications. The role of immunostaining with anti-PTH antibodies in demonstrating parathyroid gland tissue in ectopic and/or non-functioning primary tumors, as well as metastases, is also discussed.
甲状旁腺癌是原发性甲状旁腺功能亢进症的一种罕见病因。作者讨论了一例56岁男性患者的病例，该患者表现为高钙血症和多处提示肿瘤转移的骨病变。实验室和影像学检查显示，一名患有纤维囊性骨炎的患者患有原发性甲状旁腺功能亢进症，病因是纵隔甲状旁腺癌。对所有病因不明的高钙血症患者尽早测定甲状旁腺激素（PTH）水平，对于早期诊断肿瘤所致病例及预防最严重的并发症很重要。文中还讨论了使用抗PTH抗体进行免疫染色在显示异位和/或无功能原发性肿瘤以及转移灶中的甲状旁腺组织方面的作用。
