Foutz A S, Pierrefiche O, Denavit-Saubié M
Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, C.N.R.S., Gif-sur-Yvette, France.
Neuroreport. 1994 Jan 12;5(4):481-4. doi: 10.1097/00001756-199401120-00028.
We studied the effects of the non-NMDA antagonist NBQX and of the NMDA antagonist dizocilpine (MK-801), administered separately or together, on the respiratory function of conscious cats. NBQX (20 mg kg-1) did not affect minute ventilation nor the timing of inspiratory and expiratory phases, but the addition of a small dose of dizocilpine (0.15 mg kg-1) induced inspiratory pauses and respiratory arrest in the inspiratory phase (apneusis). Similarly, larger doses of either NBQX or dizocilpine did not induce apneusis but the addition of a small dose of the other compound provoked an apneusis. Thus, a blockade of either non-NMDA or NMDA receptors is well tolerated, but the combined blockade of both receptor types severely disrupts the respiratory function in the cat.
我们研究了非NMDA拮抗剂NBQX和NMDA拮抗剂地佐环平（MK-801）单独或联合给药对清醒猫呼吸功能的影响。NBQX（20毫克/千克）不影响分钟通气量，也不影响吸气和呼气阶段的时间，但添加小剂量的地佐环平（0.15毫克/千克）会导致吸气暂停和吸气相呼吸停止（窒息）。同样，单独使用较大剂量的NBQX或地佐环平不会诱发窒息，但添加小剂量的另一种化合物会引发窒息。因此，单独阻断非NMDA或NMDA受体耐受性良好，但联合阻断这两种受体类型会严重破坏猫的呼吸功能。
