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1
Similarity between pyridoxal/pyridoxamine phosphate-dependent enzymes involved in dideoxy and deoxyaminosugar biosynthesis and other pyridoxal phosphate enzymes.参与双脱氧和脱氧氨基糖生物合成的磷酸吡哆醛/磷酸吡哆胺依赖性酶与其他磷酸吡哆醛酶之间的相似性。
Protein Sci. 1994 Apr;3(4):701-5. doi: 10.1002/pro.5560030418.
2
A structural and mechanistic comparison of pyridoxal 5'-phosphate dependent decarboxylase and transaminase enzymes.
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Similarity between serine hydroxymethyltransferase and other pyridoxal phosphate-dependent enzymes.丝氨酸羟甲基转移酶与其他依赖磷酸吡哆醛的酶之间的相似性。
FEBS Lett. 1993 Sep 27;331(1-2):145-9. doi: 10.1016/0014-5793(93)80314-k.
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Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase.磷酸吡哆醛依赖性酶二烷基甘氨酸脱羧酶两种精制晶体结构的结构与机理分析
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The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme.达克纳假单胞菌天冬氨酸-β-脱羧酶十二聚体的晶体结构揭示了一种依赖于磷酸吡哆醛的酶的未知寡聚组装形式。
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Structural motifs for pyridoxal-5'-phosphate binding in decarboxylases: an analysis based on the crystal structure of the Lactobacillus 30a ornithine decarboxylase.脱羧酶中磷酸吡哆醛-5'-磷酸结合的结构基序：基于乳酸杆菌30a鸟氨酸脱羧酶晶体结构的分析。
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本文引用的文献

1
Aminotransferases: demonstration of homology and division into evolutionary subgroups.转氨酶：同源性的证明及进化亚组的划分
Eur J Biochem. 1993 Jun 1;214(2):549-61. doi: 10.1111/j.1432-1033.1993.tb17953.x.
2
Similarity between serine hydroxymethyltransferase and other pyridoxal phosphate-dependent enzymes.丝氨酸羟甲基转移酶与其他依赖磷酸吡哆醛的酶之间的相似性。
FEBS Lett. 1993 Sep 27;331(1-2):145-9. doi: 10.1016/0014-5793(93)80314-k.
3
Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites.二烷基甘氨酸脱羧酶结构：双功能活性位点和碱金属位点。
Science. 1993 Aug 6;261(5122):756-9. doi: 10.1126/science.8342040.
4
Function of the active-site lysine in Escherichia coli serine hydroxymethyltransferase.大肠杆菌丝氨酸羟甲基转移酶中活性位点赖氨酸的功能
J Biol Chem. 1993 Nov 5;268(31):23132-8.
5
Three-dimensional structure of tyrosine phenol-lyase.酪氨酸酚裂解酶的三维结构
Biochemistry. 1993 Apr 27;32(16):4195-206. doi: 10.1021/bi00067a006.
6
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.蛋白质二级结构词典：氢键和几何特征的模式识别
Biopolymers. 1983 Dec;22(12):2577-637. doi: 10.1002/bip.360221211.
7
Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.鼠伤寒沙门氏菌色氨酸合成酶α2β2多酶复合物的三维结构。
J Biol Chem. 1988 Nov 25;263(33):17857-71.
8
The beta subunit of tryptophan synthase. Clarification of the roles of histidine 86, lysine 87, arginine 148, cysteine 170, and cysteine 230.色氨酸合酶的β亚基。对组氨酸86、赖氨酸87、精氨酸148、半胱氨酸170和半胱氨酸230作用的阐明。
J Biol Chem. 1989 Apr 15;264(11):6280-7.
9
Profile analysis.轮廓分析
Methods Enzymol. 1990;183:146-59. doi: 10.1016/0076-6879(90)83011-w.
10
Substitution of glutamine for lysine at the pyridoxal phosphate binding site of bacterial D-amino acid transaminase. Effects of exogenous amines on the slow formation of intermediates.在细菌D-氨基酸转氨酶的磷酸吡哆醛结合位点用谷氨酰胺替代赖氨酸。外源胺对中间体缓慢形成的影响。
J Biol Chem. 1990 Dec 25;265(36):22306-12.

参与双脱氧和脱氧氨基糖生物合成的磷酸吡哆醛/磷酸吡哆胺依赖性酶与其他磷酸吡哆醛酶之间的相似性。

Similarity between pyridoxal/pyridoxamine phosphate-dependent enzymes involved in dideoxy and deoxyaminosugar biosynthesis and other pyridoxal phosphate enzymes.

作者信息

Pascarella S, Bossa F

机构信息

Dipartimento di Scienze Biochimiche, Università La Sapienza, Rome, Italy.

出版信息

Protein Sci. 1994 Apr;3(4):701-5. doi: 10.1002/pro.5560030418.

DOI:10.1002/pro.5560030418
PMID:8003988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2142862/
Abstract

A multiple sequence alignment among aspartate aminotransferase, dialkylglycine decarboxylase, and serine hydroxymethyltransferase (DAS) was used for profile databank search. The DAS profile could detect similarities to other pyridoxal or pyridoxamine phosphate-dependent enzymes, like several gene products involved in dideoxysugar and deoxyaminosugar synthesis. The alignment among DAS and such gene products shows the conservation of aspartate 222 and lysine 258, which, in aspartate aminotransferase, interacts with the N1 of the coenzyme pyridine ring and forms the internal Schiff base, respectively. The lysine is replaced by histidine in the pyridoxamine phosphate-dependent gene products. The alignment indicates also that the region encompassing the coenzyme binding site is the most conserved.

摘要

天冬氨酸转氨酶、二烷基甘氨酸脱羧酶和丝氨酸羟甲基转移酶（DAS）之间的多序列比对用于数据库搜索。DAS图谱可检测到与其他磷酸吡哆醛或磷酸吡哆胺依赖性酶的相似性，例如参与双脱氧糖和脱氧氨基糖合成的几种基因产物。DAS与这些基因产物之间的比对显示，天冬氨酸222和赖氨酸258保守，在天冬氨酸转氨酶中，它们分别与辅酶吡啶环的N1相互作用并形成内部席夫碱。在磷酸吡哆胺依赖性基因产物中，赖氨酸被组氨酸取代。比对还表明，包含辅酶结合位点的区域是最保守的。