家族性色素失禁症（IP2）的基因定位于Xq28的远端。
The gene for the familial form of incontinentia pigmenti (IP2) maps to the distal part of Xq28.
作者信息
Smahi A, Hyden-Granskog C, Peterlin B, Vabres P, Heuertz S, Fulchignoni-Lataud M C, Dahl N, Labrune P, Le Marec B, Piussan C
机构信息
Unité de Recherches sur les Handicaps Génétiquesde l'Enfant, INSERM U. 12, Hôpital Necker-Enfants Malades, Paris, France.
出版信息
Hum Mol Genet. 1994 Feb;3(2):273-8. doi: 10.1093/hmg/3.2.273.
Linkage data for familial incontinentia pigmenti (IP2) and 17 X chromosomal markers are reported. The linkage previously found between IP2 and the F8C locus is confirmed (Z max = 11.85 at theta = 0.028). Linkage is established with distal markers DXS1108 (Z max = 10.06 at theta = 0.00) and DXYS154 (Z = 9.07 at theta = 0.019). Multipoint analysis supports the distal localization of the IP2 gene with respect to the F8C locus.
报告了家族性色素失禁症（IP2）与17个X染色体标记的连锁数据。先前发现的IP2与F8C基因座之间的连锁关系得到确认（在θ = 0.028时，Z最大值 = 11.85）。与远端标记DXS1108（在θ = 0.00时，Z最大值 = 10.06）和DXYS154（在θ = 0.019时，Z = 9.07）建立了连锁关系。多点分析支持IP2基因相对于F8C基因座的远端定位。
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