Platinum and palladium complexes containing ethylenediamine derivatives as carrier ligands and their antitumor activity.
作者信息
Lee K, Tashiro T, Noji M
机构信息
Department of Pharmacy, Graduate School, Sookmyung Women's University Seoul, Korea.
出版信息
Chem Pharm Bull (Tokyo). 1994 Mar;42(3):702-3. doi: 10.1248/cpb.42.702.
PMID:8004720
Abstract
We prepared new antitumor active platinum complexes containing N,N'-bis(2-chloroethyl)ethylenediamine (ClEn) as an alkylating carrier ligand in order to obtain increased antitumor effects. Some of the platinum complexes synthesized showed enhanced antitumor activity. However, palladium(II) complexes containing ClEn were inactive against L1210 and P388.
摘要
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