Boutouyrie P, Lacolley P, Laurent S, London G M, Safar M E
Department of Internal Medicine, L'Institut National de la Santé et de la Recherche Médicale (U337), Broussais Hospital, Paris, France.
Clin Invest Med. 1994 Apr;17(2):97-106.
The properties of vessel walls of brachial and radial arteries were studied noninvasively, using 2 original pulsed ultrasound echo-tracking systems based on Doppler shift, in an investigation comparing 32 normotensive controls and 50 age-matched hypertensive patients. The 2 groups did not differ with respect to sex, total and high-density lipoprotein cholesterol, blood glucose, and smoking habits. Whereas noninvasive measurements of blood pressure indicated that both mean arterial pressure and pulse pressure were significantly increased in the arterial tree of the hypertensive forearm, end-diastolic diameter and pulsatile changes of the brachial and radial arteries remained within the normal range. The finding was more pronounced at the site of the radial artery in which: (i) pulsatile changes of blood pressure (documented from Finapres method) were significantly higher than those of the brachial artery, yet (ii) indices of arterial stiffness (compliance and distensibility) remained within the normal range. For the branchial artery, distensibility was significantly reduced (p = 0.01), whereas no significant change in compliance was observed. The study provides evidence that, in subjects with essential hypertension, the mechanical properties of the brachial and the radial arteries are not exclusively related to the level of blood pressure, and differ according to the arterial segment studied.
在一项比较32名血压正常的对照者和50名年龄匹配的高血压患者的研究中，使用2种基于多普勒频移的原创脉冲超声回声跟踪系统，对肱动脉和桡动脉的血管壁特性进行了无创研究。两组在性别、总胆固醇和高密度脂蛋白胆固醇、血糖及吸烟习惯方面无差异。无创血压测量表明，高血压患者前臂动脉树的平均动脉压和脉压均显著升高，而肱动脉和桡动脉的舒张末期直径及搏动变化仍在正常范围内。这一发现在桡动脉部位更为明显，在该部位：（i）（通过Finapres方法记录的）血压搏动变化显著高于肱动脉，但（ii）动脉僵硬度指标（顺应性和扩张性）仍在正常范围内。对于肱动脉，扩张性显著降低（p = 0.01），而顺应性未观察到显著变化。该研究提供了证据，在原发性高血压患者中，肱动脉和桡动脉的力学特性并非仅与血压水平相关，且根据所研究的动脉节段不同而有所差异。
