Singh S, Koke J R, Gupta P D, Malhotra S K
Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India.
Cytobios. 1994;77(308):41-57.
The widespread distribution, diversity of types, and highly conserved features of intermediate filaments (IFs) and the diversity of associated proteins indicate multiple roles for IFs in the nucleus and the cytoplasm of eukaryotic cells. Traditional functions include maintenance of cell shape, cell locomotion, movement and positioning of organelles and guiding cell development. Recent studies indicate some of these functions can now be expanded. Currently available information shows that IFs are important to nuclear function and cell division, to transport between the nucleus and cytoplasm, to the mechanical integrity of cells and tissues, to reorganization of the cytoplasm and chromatin in response to intercellular signals, and to embryonic and cellular differentiation.
中间丝（IFs）广泛的分布、多样的类型、高度保守的特征以及相关蛋白的多样性表明，IFs在真核细胞的细胞核和细胞质中具有多种作用。传统功能包括维持细胞形状、细胞运动、细胞器的移动和定位以及引导细胞发育。最近的研究表明，其中一些功能现在可以扩展。目前可得的信息显示，IFs对于核功能和细胞分裂、细胞核与细胞质之间的运输、细胞和组织的机械完整性、响应细胞间信号的细胞质和染色质重组以及胚胎和细胞分化都很重要。
