de Almeida M M, Chagas M, de Sousa J V, Mendonça M E
Laboratório de Citologia, Instituto Português de Oncologia de Francisco Gentil, Lisboa.
Diagn Cytopathol. 1994;10(1):44-6. doi: 10.1002/dc.2840100112.
Fine-needle aspiration cytology (FNAC) of the testis was done in 31 children (33 aspirates) with acute lymphoblastic leukemia (ALL) either as part of an end-therapy protocol (Group I, n = 20) or because of clinical suspicion of testicular relapse (Group II, n = 13). In Group I, none of the smears showed evidence of leukemic cells. However, two of these patients developed subsequent testicular relapse within 1 yr and were considered false-negative cases. Blast cells were present in nine patients of Group II; in the remaining four patients no neoplastic cells were observed in the smears and none experienced a relapse after a mean follow-up of 18 mo. Our findings indicate that FNAC can be a valuable method to evaluate clinically suspected testicular infiltration in children with ALL, and can be considered as an alternative procedure to surgical biopsy for screening testicular recurrence of childhood ALL.
对31名患有急性淋巴细胞白血病（ALL）的儿童（共33次穿刺）进行了睾丸细针穿刺细胞学检查（FNAC），这些儿童要么作为治疗结束方案的一部分（第一组，n = 20），要么是因为临床怀疑睾丸复发（第二组，n = 13）。在第一组中，没有涂片显示有白血病细胞的迹象。然而，这些患者中有2例在1年内随后出现睾丸复发，被视为假阴性病例。第二组中有9名患者存在原始细胞；其余4名患者的涂片未观察到肿瘤细胞，平均随访18个月后均未复发。我们的研究结果表明，FNAC可以作为评估ALL儿童临床怀疑的睾丸浸润的一种有价值的方法，并且可以被视为筛查儿童ALL睾丸复发的手术活检的替代方法。
