位于12号染色体上的人类胰腺磷脂酶A2（PLA2）基因中的TaqI双态位点。

TaqI dimorphic site in a human pancreatic phospholipase A2 (PLA2) gene localized on chromosome 12.

作者信息

Frossard P M, Newman P E, Lestringant G G

机构信息

Department of Pathology, Faculty of Medicine and Health Sciences, Al Ain, United Arab Emirates.

出版信息

Hum Genet. 1994 Jun;93(6):720. doi: 10.1007/BF00201582.

DOI:10.1007/BF00201582

PMID:8005604

Abstract

We report the identification of a TaqI dimorphic site in the first intron of a human phospholipase A2 gene that has been localized on chromosome 12. This single two-allele polymorphism was detected by DNA blot hybridization using a full-length, 584 bp human phospholipase A2 cDNA isolated from a human lung lambda gt10 cDNA library. Fragment lengths were detected at either 1.3 kb or 2.2 kb. The PIC value of this dimorphism was 0.369 in a random population of 353 Caucasians.

摘要

我们报告了在人类磷脂酶A2基因的第一个内含子中鉴定出一个TaqI双态位点，该基因已定位在12号染色体上。使用从人肺λgt10 cDNA文库中分离出的全长584 bp的人磷脂酶A2 cDNA，通过DNA印迹杂交检测到这种单双等位基因多态性。片段长度检测为1.3 kb或2.2 kb。在353名高加索人的随机群体中，这种双态性的PIC值为0.369。