铁蛋白对脂多糖增强的骨髓生成的单核因子抑制剂的刺激是依赖于铁氧化酶的。
Ferritin stimulation of a monokine inhibitor of lipopolysaccharide-augmented myelopoiesis is ferroxidase dependent.
作者信息
Kreisberg R, Broxmeyer H E, Moore R N
机构信息
Department of Microbiology, University of Tennessee, Knoxville 37996-0845.
出版信息
Infect Immun. 1994 Jul;62(7):2991-4. doi: 10.1128/iai.62.7.2991-2994.1994.
Abstract
Ferritin inhibition of myelopoiesis has been associated with intrinsic ferroxidase activity of heavy-chain ferritin and with production of a monokine inhibitor of lipopolysaccharide (LPS)-augmented monocytopoiesis. We report here that intrinsic ferroxidase activity of heavy-chain ferritin is required for stimulated production of the monokine inhibitor of LPS-augmented monocytopoiesis.
摘要
铁蛋白对骨髓生成的抑制作用与重链铁蛋白的内在亚铁氧化酶活性以及脂多糖（LPS）增强的单核细胞生成的单核因子抑制剂的产生有关。我们在此报告，重链铁蛋白的内在亚铁氧化酶活性是刺激产生LPS增强的单核细胞生成的单核因子抑制剂所必需的。
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