Orlov M V, Brodsky M A, Douban S
University of California, Irvine Medical Center, Orange.
J Am Coll Nutr. 1994 Apr;13(2):127-32. doi: 10.1080/07315724.1994.10718384.
Many years ago, experimental medicine accumulated substantial evidence that magnesium (Mg) balance was important for a stable cardiovascular system. Recent clinical interest was aroused by evidence of decreased mortality in patients with acute myocardial infarction (AMI), treated with Mg infusions. Pharmacologic actions of Mg include its antiarrhythmic, antivasospastic and other important cardiovascular effects, substantiating the rationale for its use in AMI. Direct pharmacologic effect of this ion, rather than compensation of hypomagnesemia frequently encountered during acute ischemic injury, has been suggested to account for the above benefits. Several trials studied the efficacy of early Mg therapy in decreasing mortality from AMI while most of the data point to improved survival, a few trials could not demonstrate any benefit of Mg. The reported rate of complications with this therapy is low though the potential for serious side effects exists. Larger studies of Mg in AMI are expected to resolve the existing controversy.
许多年前，实验医学积累了大量证据，表明镁（Mg）平衡对稳定心血管系统很重要。近期，急性心肌梗死（AMI）患者输注镁后死亡率降低的证据引发了临床关注。镁的药理作用包括抗心律失常、抗血管痉挛及其他重要的心血管效应，这为其在AMI中的应用提供了理论依据。有人认为，上述益处是该离子的直接药理作用所致，而非急性缺血性损伤时常见的低镁血症的代偿作用。多项试验研究了早期镁治疗在降低AMI死亡率方面的疗效，尽管大多数数据表明生存率有所提高，但有少数试验未能证明镁有任何益处。尽管这种治疗存在严重副作用的可能性，但报告的并发症发生率较低。预计针对AMI患者进行的更大规模镁治疗研究将解决现有争议。
