Munakata M, Ukita H, Masaki Y, Doi I, Ohtsuka Y, Ohe M, Amishima M, Chen H, Nasuhara Y, Taguchi H
First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Dec;31 Suppl:154-8.
The importance of airway inflammation in the pathophysiology of bronchial asthma has been recognized recently. This inflammation is organized by the interaction between inflammatory cells and the cells which compose airway structures. We studied the role of airway epithelium in airway hyperresponsiveness and airway inflammation, which are the major characteristics of bronchial asthma, and demonstrated a close relationship between them. On the bases of these data and the data reported by many other researchers, and from the point of view of airway inflammation, we discussed the possible roles of airway epithelium in bronchial asthma.
气道炎症在支气管哮喘病理生理学中的重要性最近已得到认可。这种炎症是由炎症细胞与构成气道结构的细胞之间的相互作用所组织的。我们研究了气道上皮在气道高反应性和气道炎症中的作用，这两者是支气管哮喘的主要特征，并证明了它们之间的密切关系。基于这些数据以及许多其他研究人员报告的数据，并且从气道炎症的角度出发，我们讨论了气道上皮在支气管哮喘中可能发挥的作用。
