Yamada S, Yokoo H, Nishi S
Department of Pharmacology, Kurume University School of Medicine, Japan.
Kurume Med J. 1993;40(4):243-7. doi: 10.2739/kurumemedj.40.243.
The effects of the benzamide derivatives, (-)-sulpiride, sultopride and nemonapride, on spontaneous and electrically evoked dopamine (DA) release from striatal slices of rats were investigated. Nemonapride at concentrations of 100 nM or higher caused a dose-dependent increase in spontaneous DA release from the slices. (-)-Sulpiride and sultopride had little effect on spontaneous DA release. The electrically evoked DA release was enhanced by (-)-sulpiride at concentrations of 100 nM or higher in the superfusate and reduced by nemonapride at 100 nM or higher. Sultopride caused a small increase in the evoked release of DA. The different activities of these drugs on DA release may account for the different clinical results they produce.
研究了苯甲酰胺衍生物（-）舒必利、舒托必利和奈莫必利对大鼠纹状体切片中多巴胺（DA）自发释放和电诱发释放的影响。浓度为100 nM或更高的奈莫必利可使切片中DA的自发释放呈剂量依赖性增加。（-）舒必利和舒托必利对DA的自发释放几乎没有影响。在灌注液中，浓度为100 nM或更高的（-）舒必利可增强电诱发的DA释放，而浓度为100 nM或更高的奈莫必利则可使其降低。舒托必利可使诱发的DA释放略有增加。这些药物对DA释放的不同作用可能解释了它们产生的不同临床效果。
