Koyama Y, Hayaishi O
Osaka Bioscience Institute, Japan.
Neurosci Res. 1994 Feb;19(1):31-8. doi: 10.1016/0168-0102(94)90005-1.
The basal forebrain including the preoptic area and anterior hypothalamus plays an important role in regulation of slow wave sleep. To examine whether this area is concerned also in a neural mechanism of paradoxical sleep, single neuronal activity in and around the preoptic area along with cortical EEG and neck EMG was recorded in undrugged, 12-h sleep-deprived rats whose head was fixed painlessly. The neurons whose activity was recorded during all states of sleep and wakefulness (n = 98) were classified into following 5 groups according to their firing behavior in relation to sleep-waking states. (1) Neurons most active during paradoxical sleep (n = 26). (2) Those most inactive during paradoxical sleep, some of which were inactive also during slow wave sleep (n = 16). (3) Those specifically active during slow wave sleep (n = 14). (4) Those less active during slow wave sleep than during wakefulness and paradoxical sleep (n = 9). (5) Those whose activity showed no clear correlation with the sleep-waking states (n = 33). About one third of neurons in each of groups (1) to (4) began to increase their sleep-related activity in advance of the shift of sleep/wakefulness state recognized in EEG. These results suggest that the preoptic and anterior hypothalamic areas are involved, at least in rats, in regulation of not only slow wave sleep but also paradoxical sleep.
包括视前区和下丘脑前部在内的基底前脑在慢波睡眠的调节中起重要作用。为了研究该区域是否也参与异相睡眠的神经机制，在未用药、睡眠剥夺12小时且头部无痛固定的大鼠中，记录了视前区及其周围的单个神经元活动以及皮层脑电图和颈部肌电图。根据其在睡眠 - 觉醒状态下的放电行为，将在所有睡眠和觉醒状态下记录到活动的神经元（n = 98）分为以下5组。（1）在异相睡眠期间最活跃的神经元（n = 26）。（2）在异相睡眠期间最不活跃的神经元，其中一些在慢波睡眠期间也不活跃（n = 16）。（3）在慢波睡眠期间特别活跃的神经元（n = 14）。（4）在慢波睡眠期间比在觉醒和异相睡眠期间活动较少的神经元（n = 9）。（5）其活动与睡眠 - 觉醒状态无明显相关性的神经元（n = 33）。在（1）至（4）组中的每组神经元中，约三分之一在脑电图中识别出的睡眠/觉醒状态转变之前就开始增加其与睡眠相关的活动。这些结果表明，至少在大鼠中，视前区和下丘脑前部区域不仅参与慢波睡眠的调节，也参与异相睡眠的调节。
