Grzeszczak W, Kowalska K, Kowalski D
Katedra i Klinika Chorób Wewnetrznych i Zawodowych Slaskiej Akademii Medycznej, Zabrzu.
Pol Arch Med Wewn. 1994 Feb;91(2):84-9.
The aim of the study was to answer 3 questions: 1. does plasma endothelin level differ in patients with chronic renal failure from that of healthy subjects. 2. does plasma endothelin level differ in patients with chronic renal failure treated with haemodialysis from those treated without dialysis. 3. does plasma endothelin level change during haemodialysis. 63 patients with chronic renal failure (pnn, 23 treated without dialyses and 40 with dialyses) as well as 20 healthy subjects were studied. Plasma endothelin and creatinine were estimated under basal conditions and in the dialysed patients--immediately after dialysis. Plasma endothelin level was higher in patients with pnn than in normals, regardless to dialysotherapy. It rose after dialysis. Plasma creatinine fell after dialysis. Positive significant correlation was found between the levels of creatinine and endothelin in the whole group studied.
本研究的目的是回答3个问题：1. 慢性肾衰竭患者的血浆内皮素水平与健康受试者的是否不同。2. 接受血液透析治疗的慢性肾衰竭患者与未接受透析治疗的患者的血浆内皮素水平是否不同。3. 血液透析过程中血浆内皮素水平是否变化。研究了63例慢性肾衰竭患者（23例未接受透析治疗，40例接受透析治疗）以及20名健康受试者。在基础条件下对血浆内皮素和肌酐进行了测定，对于接受透析治疗的患者，在透析后立即进行测定。无论透析治疗情况如何，慢性肾衰竭患者的血浆内皮素水平均高于正常受试者。透析后其水平升高。透析后血浆肌酐水平下降。在整个研究组中，肌酐水平与内皮素水平之间存在显著正相关。
