Gordon S, Lee S
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Mod Pathol. 1994 Feb;7(2):166-8.
Naked megakaryocyte nuclei (NMN) were studied retrospectively in 100 bone marrow biopsy sections and aspirates from patients with acquired immunodeficiency syndrome (AIDS) and 124 non-AIDS controls. An NMN score was developed to semiquantitate the NMN. The AIDS bone marrows had an incidence of 97% and a mean NMN score of 2.24 which was a higher incidence and score than the control groups and was statistically significant. The control groups consisted of 20 chronic myeloproliferative disorders (incidence of 70% and score of 1.4); 24 cases of acute myelogenous leukemia and myelodysplastic syndrome (incidence of 29.2% and 0.46 score); 22 cases of non-AIDS immune thrombocytopenic purpura (incidence of 50% and 0.82 score); 11 cases of acute lymphocytic leukemia (0% incidence); 21 cases of anemia (52.4% incidence and 0.7 score); and 26 cases of lymphoma staging (35% incidence and 0.35 score). It is concluded that NMN are a very frequent and, with a high score, a specific finding in AIDS bone marrow examinations.
对100例获得性免疫缺陷综合征（AIDS）患者的骨髓活检切片和抽吸物以及124例非AIDS对照进行了裸巨核细胞核（NMN）的回顾性研究。制定了NMN评分以对NMN进行半定量。AIDS患者骨髓中NMN的发生率为97%，平均评分为2.24，其发生率和评分均高于对照组，具有统计学意义。对照组包括20例慢性骨髓增殖性疾病（发生率为70%，评分为1.4）；24例急性髓细胞白血病和骨髓增生异常综合征（发生率为29.2%，评分为0.46）；22例非AIDS免疫性血小板减少性紫癜（发生率为50%，评分为0.82）；11例急性淋巴细胞白血病（发生率为0%）；21例贫血（发生率为52.4%，评分为0.7）；以及26例淋巴瘤分期（发生率为35%，评分为0.35）。结论是，NMN在AIDS骨髓检查中是非常常见的，且评分高时是一项特异性发现。
