Halse J, Nordal K P, Attramadal A, Dahl E
Medisinsk avdeling B, Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 1994 Feb 10;114(4):439-42.
Idiopathic osteoporosis is uncommon in middle-aged men. We discuss nine otherwise healthy men aged from 35 to 57 years, eight of whom were shown to be osteoporotic when subjected to detailed investigation because of back pain. None had suffered fractures of the appendicular skeleton as adults. All had an ordinary life style and ate a normal diet. Lumbar spine bone density was greatly reduced in all nine patients, while six of them showed normal values for cortical bone density in the forearm. Bone histomorphometry showed high turnover of bone tissue, with high bone resorption and lower than average bone formation. Serum osteocalcin levels were low in all nine patients, but alkaline phosphatase was higher than the upper normal limit in six of them. The etiology of the disease is unknown, but the pathogenesis is a result of disparity between formation and resorption of bone tissue. Unidentified environmental factors may be one of the reasons for the appearance of idiopathic osteoporosis as a "new" disease among middle-aged men.
特发性骨质疏松症在中年男性中并不常见。我们讨论了9名年龄在35至57岁之间的健康男性，其中8人因背痛接受详细检查时被发现患有骨质疏松症。这些患者成年后均未发生过四肢骨骼骨折。他们都生活方式正常，饮食也正常。所有9例患者的腰椎骨密度均显著降低，而其中6例患者前臂皮质骨密度值正常。骨组织形态计量学显示骨组织转换率高，骨吸收增加且骨形成低于平均水平。所有9例患者血清骨钙素水平均较低，但其中6例碱性磷酸酶高于正常上限。该病病因不明，但其发病机制是骨组织形成与吸收失衡的结果。不明环境因素可能是特发性骨质疏松症作为一种“新”疾病在中年男性中出现的原因之一。
