[Role of the endocrine function of the islands of Langerhans in the mechanism of development of hypothalamic obesity].

Administration of alloxan to rats which developed hypothalamic adiposity damaged the pancreatic beta-cells and reduced the insulin secretion, thus arresting further weight gain despite some excess in food ingestion. A conclusion was drawn that in injury of the ventro-medial nuclei of the hypothalamus the most significant mechanism of obesity development was insulin hypersecretion induced by this action.