米非司酮和依普孕酮单独及联合应用对大鼠的抗生育作用

[Antifertility effects of mifepristone and epostane alone and in combination in rats].

作者信息

Liu C G, Lin Z M, Li W K, Wu X Y, Wang Z X, Xue T, Xu R Y

机构信息

Shanghai Institute of Planned Parenthood Research, China.

出版信息

Zhongguo Yao Li Xue Bao. 1993 Sep;14(5):437-40.

PMID:8010036

Abstract

A complete interceptive action on pregnancy was shown after ig mifepristone (RU-486) 16 mg.kg-1 or epostane 96 mg.kg-1 on d 10 of pregnancy in rats. The ig ED50 (95% fiducial limits) of RU-486 when given alone and in combination with epostane 12 mg.kg-1 were found to be 7.8 (5.3-10.0) and 2.6 (2.0-3.3) mg.kg-1, respectively (P < 0.05), while those of epostane when given alone and in combination with RU-486 4 mg.kg-1 were 25.5 (19.4-33.6) and 5.6 (4.7-7.4) mg.kg-1, respectively (P < 0.05). An absorption promotor, sodium dodecyl sulfate 24 mg.kg-1 ig, when given in combination with RU-486 8 mg.kg-1 or epostane 24 mg.kg-1, induced complete interceptive action on pregnancy. Levels of plasma progesterone declined significantly when epostane 12 mg.kg-1 was given in combination with RU-486 4 mg.kg-1 as compared with epostane 12 mg.kg-1 alone (P < 0.05). Results showed that drug combination therapy was of benefit both to RU-486 and epostane in their interceptive actions.

摘要

在大鼠妊娠第10天给予米非司酮（RU - 486）16mg·kg⁻¹或依波斯坦96mg·kg⁻¹后，显示出对妊娠的完全阻断作用。单独给予RU - 486以及与12mg·kg⁻¹依波斯坦联合使用时，其ig ED50（95%置信限）分别为7.8（5.3 - 10.0）和2.6（2.0 - 3.3）mg·kg⁻¹（P < 0.05）；而单独给予依波斯坦以及与4mg·kg⁻¹ RU - 486联合使用时，其ig ED50分别为25.5（19.4 - 33.6）和5.6（4.7 - 7.4）mg·kg⁻¹（P < 0.05）。一种吸收促进剂，即24mg·kg⁻¹ ig的十二烷基硫酸钠，与8mg·kg⁻¹ RU - 486或24mg·kg⁻¹依波斯坦联合使用时，可诱导对妊娠的完全阻断作用。与单独给予12mg·kg⁻¹依波斯坦相比，当12mg·kg⁻¹依波斯坦与4mg·kg⁻¹ RU - 486联合使用时，血浆孕酮水平显著下降（P < 0.05）。结果表明，联合药物治疗对RU - 486和依波斯坦的阻断作用均有益处。