硝苯地平对兔输卵管收缩运动及纤毛超微结构的影响
[Effect of nifedipine on contractive motility and ciliary ultrastructure of rabbit fallopian tube].
作者信息
Yang L, Xu Y X
机构信息
Department of Pharmacology, Xi-an Medical University, China.
出版信息
Zhongguo Yao Li Xue Bao. 1993 Sep;14(5):450-2.
The effects of nifedipine (Nif) on the motility of isolated isthmus of rabbit Fallopian tube were studied in comparison with those of verapamil (Ver) and cinnarizine (Cin). Nif (0.01 mumol.L-1), Ver (0.03 mumol.L-1), and Cin (3 mumol/L-1) inhibited the spontaneous contraction, and the contraction caused by norepinephrine (NE). The pD'2 values of Nif, Ver, and Cin were 6.86, 6.13, and 4.43, respectively. Moreover, both Nif and Ver delayed the ovum transport through the Fallopian tube 48 h after iv chorionic gonadotropin (HCG). Nif did not modify the ultrastructure of the ampulla ciliary microtubule, but it influenced the mitochondrial structure and caused an irregular ciliary motion.
研究了硝苯地平（Nif）对兔输卵管孤立峡部运动的影响，并与维拉帕米（Ver）和桂利嗪（Cin）进行比较。Nif（0.01μmol·L-1）、Ver（0.03μmol·L-1）和Cin（3μmol/L-1）抑制自发收缩以及去甲肾上腺素（NE）引起的收缩。Nif、Ver和Cin的pD'2值分别为6.86、6.13和4.43。此外，在静脉注射绒毛膜促性腺激素（HCG）48小时后，Nif和Ver均延迟了卵子通过输卵管的运输。Nif未改变壶腹睫状微管的超微结构，但影响线粒体结构并导致不规则的睫状运动。
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