Dong H, Liang Z J, Yang Z C
Department of Biophysics, School of Basic Medical Sciences, Shanghai Medical University, China.
Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):517-9.
1-(2-[(6-Methoxyl)-naphthylmethyl)])-1-methyl-N-piperidinylacethyl -6,7- dimethoxyl-1,2,3,4-tetrahydroisoquinoline (CPU-23), a substituted tetrahydroisoquinoline, reduced the voltages of P wave and J point, prolonged PR interval, and slowed sinus rhythm of ECG in spontaneously hypertensive rats (SHR) and age-matched normotensive WKY rats. The effects of CPU-23 on cardiac electric activity were stronger in SHR than in WKY rats (P < 0.05 or P < 0.01). The results suggest that CPU-23 have a calcium antagonistic activity on rat hearts and that calcium antagonists may exert a stronger inhibition of the cardiac electric activity in hypertensive rats than in normotensive rats.
1-（2-[(6-甲氧基)-萘甲基]）-1-甲基-N-哌啶基乙酰基-6,7-二甲氧基-1,2,3,4-四氢异喹啉（CPU-23），一种取代的四氢异喹啉，降低了自发性高血压大鼠（SHR）和年龄匹配的正常血压WKY大鼠的P波和J点电压，延长了PR间期，并减慢了心电图的窦性心律。CPU-23对心脏电活动的影响在SHR中比在WKY大鼠中更强（P<0.05或P<0.01）。结果表明，CPU-23对大鼠心脏具有钙拮抗活性，并且钙拮抗剂对高血压大鼠心脏电活动的抑制作用可能比正常血压大鼠更强。
