Wu W Z, Yang Y Z, Jin P Y, Liu Z Y, Zhuang Y C, Zhuang W Y, Gu J K, Gu Y M
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical University, China.
Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):520-2.
Anti-arrhythmic effects of captopril (Cap) were studied in the anesthetized pigs using a reversible balloon catheter. Results showed that Cap did not exert any influence on the weight percentage of ischemic area to the whole left ventricle, on the levels of serum creatine kinase (CK) and creatine kinase isozyme (CK-MB), nor on the incidence and duration of transient and persistent tachycardia, but reduced the incidence of ventricular fibrillation (2/12, 1/12 in high-dose group pigs treated with Cap 6 mg.kg-1 in the first 10 min, 25 micrograms.kg-1.min-1 in the later 90 min and 12/21, 11/21 in control group treated with normal saline through the occlusion and reperfusion periods, respectively, P < 0.05). It was suggested that Cap did not exhibit direct (or non-specific, if any) effects on anti-arrhythmias.
使用可逆转气囊导管，在麻醉猪身上研究了卡托普利（Cap）的抗心律失常作用。结果显示，Cap对缺血区域占整个左心室的重量百分比、血清肌酸激酶（CK）和肌酸激酶同工酶（CK-MB）水平均无影响，对短暂性和持续性心动过速的发生率及持续时间也无影响，但降低了心室颤动的发生率（高剂量组猪在最初10分钟静脉注射6mg·kg-1卡托普利，随后90分钟静脉滴注25μg·kg-1·min-1，心室颤动发生率为2/12、1/12；在整个闭塞和再灌注期经静脉输注生理盐水的对照组，心室颤动发生率分别为12/21、11/21，P<0.05）。提示Cap对心律失常无直接（或非特异性，如果存在）作用。
