Rao M R, Liu Q Y, Jia S L
Department of Cardiovascular Pharmacology, Nanjing Medical College, China.
Zhongguo Yao Li Xue Bao. 1993 Nov;14 Suppl:S25-7.
In anesthetized dogs intraduodenal administration of m-nifedipine (m-Nif) 0.4 mg.kg-1, coronary flow increased from 708 +/- 72 to 880 +/- 150 ml.min-1.kg-1 (+24%) at 5 min, to 1976 +/- 350 ml.min-1.kg-1 (+179%) at 30 min, and to 998 +/- 250 ml.min-1.kg-1 (+41%) at 4 h. At the dose of nifedipine (Nif), coronary flow increased from 778 +/- 91 to 1080 +/- 90 ml.min-1.kg-1 (+39%) at 3 min and to 1836 +/- 280 ml.min-1.kg-1 (+136%) at 90 min. m-Nif was more 43% potent than Nif and the duration of action of m-Nif was longer. m-Nif reduced heart rate by -39%, while Nif reduced only -11%. m-Nif increased coronary sinus O2 content and reduced MVO2, and no difference was seen between these 2 drugs. However, the rate of CO2 production with m-Nif was reduced to a greater degree than that of Nif. The results indicated that m-Nif was more beneficial in alleviating myocardial ischemia than that of Nif.
在麻醉犬中，十二指肠内给予0.4mg·kg⁻¹的间硝苯地平（m-Nif），冠状动脉血流量在5分钟时从708±72增加至880±150ml·min⁻¹·kg⁻¹（增加24%），30分钟时增加至1976±350ml·min⁻¹·kg⁻¹（增加179%），4小时时增加至998±250ml·min⁻¹·kg⁻¹（增加41%）。给予硝苯地平（Nif）时，冠状动脉血流量在3分钟时从778±91增加至1080±90ml·min⁻¹·kg⁻¹（增加39%），90分钟时增加至1836±280ml·min⁻¹·kg⁻¹（增加136%）。m-Nif的效力比Nif高43%，且m-Nif的作用持续时间更长。m-Nif使心率降低39%，而Nif仅使心率降低11%。m-Nif增加了冠状窦氧含量并降低了心肌耗氧量，这两种药物之间未见差异。然而，m-Nif使二氧化碳产生率的降低程度大于Nif。结果表明，m-Nif在缓解心肌缺血方面比Nif更有益。
