Xing S H, Ge X Q, Yan M, Bian C F
Department of Pharmacology, Xuzhou Medical College, China.
Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):92-6.
Administration of dl-tetrahydropalmatine (THP) i.v., ip, and ig lowered the pressure and concurrently slowed the heart rate in anesthetized rats. The hypotensive and bradycardic effects were not produced by injecting THP into the vertebral artery in anesthetized rabbits. These results suggest that the site of hypotensive action of THP may not be a central one. The HPLC coupled with electrochemical detection showed that the contents of norepinephrine (NE) in the heart, aorta, and femoral artery and epinephrine (E) in the adrenal gland were markedly reduced by THP (P < 0.01). A positive correlation was found between the hypotensive effect and the reduction of NE in the aorta and femoral artery (r = 0.97, P < 0.01).
静脉内、腹腔内和灌胃给予消旋四氢巴马汀（THP）可降低麻醉大鼠的血压，并同时减慢心率。在麻醉兔中，将THP注入椎动脉未产生降压和心动过缓作用。这些结果表明，THP降压作用的部位可能不在中枢。高效液相色谱-电化学检测显示，THP可使心脏、主动脉和股动脉中的去甲肾上腺素（NE）含量以及肾上腺中的肾上腺素（E）含量显著降低（P<0.01）。发现降压作用与主动脉和股动脉中NE的降低之间呈正相关（r = 0.97，P<0.01）。
