Zhang H L, Yang Y R, Wang Y, Zheng P, Wang H C, Lao A N
Department of Pharmacology, Baotou Medical College, China.
Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):176-80.
In the rat hot plate test, vocalization induced by electric stimulation, tail flick test, and the mouse acetic acid writhing test, 3, 15-diacetylbenzoylaconine (DABA) ip exhibited a dose-dependent analgesic activity. Intrathecally (ith) administered DABA (527, 1186 micrograms.kg-1) had no analgesic action. Microinjection of DABA 35-75 micrograms.kg-1 or 20 micrograms into the cerebral ventricle (icv) or the periaqueductal gray (PAG) exerted a remarkable analgesic activity, which was abolished after bilateral lesions of locus coeruleus (LC). Microinjection of DABA (20 micrograms) into LC failed to produce apparent analgesic action. These results suggested that the sites of analgesia of DABA were mainly at the central supraspinal structures, and PAG was one of the primary sites, while LC was one of the intermediate links.
在大鼠热板试验、电刺激诱发发声试验、甩尾试验以及小鼠醋酸扭体试验中，腹腔注射3,15 - 二乙酰苯甲酰乌头碱（DABA）呈现出剂量依赖性镇痛活性。鞘内注射DABA（527、1186微克·千克⁻¹）无镇痛作用。脑室内（icv）或中脑导水管周围灰质（PAG）微量注射35 - 75微克·千克⁻¹或20微克DABA可产生显著的镇痛活性，在双侧蓝斑（LC）损毁后该活性消失。向LC微量注射DABA（20微克）未能产生明显的镇痛作用。这些结果表明，DABA的镇痛部位主要在中枢脊髓上结构，PAG是主要部位之一，而LC是中间环节之一。
