Mandai K, Sueyoshi K, Fukunaga R, Nukada M, Ohtani F, Araki Y, Tsukaguchi I, Abe H
Department of Internal Medicine, Osaka Rosai Hospital, Japan.
AJNR Am J Neuroradiol. 1994 Apr;15(4):659-65.
We compared three-dimensional time-of-flight MR angiograms obtained before and after acetazolamide administration to evaluate whether use of this drug could improve visualization of small peripheral intracranial arteries and atherosclerotic stenosis.
For evaluation of small peripheral arteries, 10 patients with clinical diagnosis of ischemic cerebrovascular disease and 10 healthy volunteers were investigated, and for evaluation of stenosis, another 6 patients were investigated. Vascular images were obtained by three-dimensional time-of-flight MR angiography. After a baseline scan, 17 mg/kg acetazolamide was injected intravenously and the second scan was performed 20 minutes later.
Several small peripheral arteries that had not been seen on the baseline images were visible on the acetazolamide images without any augmentation of the background signals. Stenotic lesions in the main trunks of the major cerebral arteries were detected more clearly on acetazolamide images.
Acetazolamide improves visualization of small peripheral intracranial arteries and sensitivity in detecting atherosclerotic stenosis in the main trunk of major cerebral artery by three-dimensional time-of-flight MR angiography without changing MR apparatus and software.
我们比较了乙酰唑胺给药前后获得的三维时间飞跃磁共振血管造影，以评估使用该药物是否能改善颅内小外周动脉的可视化以及动脉粥样硬化狭窄情况。
为评估小外周动脉，对10例临床诊断为缺血性脑血管疾病的患者和10名健康志愿者进行了研究，为评估狭窄情况，又对另外6例患者进行了研究。通过三维时间飞跃磁共振血管造影获取血管图像。在基线扫描后，静脉注射17mg/kg乙酰唑胺，20分钟后进行第二次扫描。
在乙酰唑胺图像上可见一些在基线图像上未显示的小外周动脉，且背景信号未增强。在乙酰唑胺图像上能更清晰地检测到大脑主要动脉主干中的狭窄病变。
乙酰唑胺可通过三维时间飞跃磁共振血管造影改善颅内小外周动脉的可视化，并提高检测大脑主要动脉主干中动脉粥样硬化狭窄的敏感性，且无需更换磁共振设备和软件。
