Leidenix M, Mamalis N, Goodart R, Harrie R, Kjeldsberg C
Intermountain Ocular Research Center, Department of Ophthalmology, University of Utah, Salt Lake City.
Ann Ophthalmol. 1994 Mar-Apr;26(2):42-6.
A 26-year-old man presented with an insidious loss of vision OD. He had amblyopia OD as a child secondary to congenital esotropia. Ophthalmic examination revealed a large mass beneath his right retina near the posterior pole. He also had glaucoma and a rapidly developing cataract. Ultrasound detected a choroidal mass, which was consistent with a melanoma. The patient chose enucleation over radiation therapy as his treatment modality. Pathologic evaluation of the tumor revealed a necrotic melanocytoma with a large malignant melanoma arising from its center that was comprised mainly of epithelioid cells. Malignant melanoma arising in a necrotic melanocytoma is an extremely rare event, and we believe this to be the first description of this event in a young patient with an amblyopic eye.
一名26岁男性因右眼视力逐渐丧失前来就诊。他自幼因先天性内斜视患有右眼弱视。眼科检查发现其右视网膜后极附近有一个巨大肿物。他还患有青光眼和快速发展的白内障。超声检查发现脉络膜肿物，与黑色素瘤相符。患者选择眼球摘除术而非放射治疗作为其治疗方式。肿瘤的病理评估显示为坏死性黑素细胞瘤，其中心有一个主要由上皮样细胞组成的巨大恶性黑色素瘤。坏死性黑素细胞瘤中发生恶性黑色素瘤是极其罕见的事件，我们认为这是对一名患有弱视的年轻患者中该事件的首次描述。
