Iqbal M P, Ashfaq M K, Niazi S K, Mahboobali M, Khawaja K N
Department of Biochemistry, Aga Khan University, Karachi, Pakistan.
Biopharm Drug Dispos. 1994 Mar;15(2):173-7. doi: 10.1002/bdd.2510150209.
Pharmacokinetic parameters of two antifolates, trimethoprim and aditoprim, were studied in buffalo calves. The elimination half-life of aditoprim (6.14 h) was nearly twice as long as that of trimethoprim (3.08 h) and compares well with values observed in heifers. This longer half-life of aditoprim is a result of its much larger distribution volume (four to five times larger) because the clearance of aditoprim was about twice as high as that of trimethoprim. The longer half-life of aditoprim is expected to give a longer duration of in vivo bacteriostatic activity than that of trimethoprim.
