Di Blasio B, Pavone V, Saviano M, Fattorusso R, Pedone C, Benedetti E, Crisma M, Toniolo C
University of Naples, Italy.
Pept Res. 1994 Mar-Apr;7(2):55-9.
A crystal-state structural analysis of the terminally blocked apolar decapeptide pBrBz-(Aib-L-Ala)5-OMe bis-dimethylsulfoxide solvate was performed by x-ray diffraction. The peptide molecules are basically alpha-helical with five 1<--5 C = O... H-N intramolecular H bonds. Near the C terminus the regularity of the alpha-helix is disrupted in favor of the formation of intramolecular H bonds of the 1<--4 (beta-bend) and 1<--6 (pi-bend) types. Differences in conformation, solvation and association with the published structure of the tetrahydrate decapeptide polymorph are discussed.
通过X射线衍射对末端封闭的非极性十肽pBrBz-(Aib-L-Ala)5-OMe双二甲亚砜溶剂化物进行了晶体状态结构分析。肽分子基本上呈α-螺旋结构，具有五个1<--5 C = O... H-N分子内氢键。在C末端附近，α-螺旋的规则性被破坏，有利于形成1<--4（β-转角）和1<--6（π-转角）类型的分子内氢键。讨论了该化合物与已发表的十肽四水合物多晶型结构在构象、溶剂化和缔合方面的差异。
