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[系统暴露于+Gz过载下的红细胞功能]

[Red blood function in systematic exposure to +Gz g-forces].

作者信息

Dlusskaia I G, Kiseleva R K, Vartbaronov R A, Khomenko M N, Kozinets G I, Bondarenko R A, Bukhtiiarov I V

出版信息

Aviakosm Ekolog Med. 1993 Mar-Apr;27(2):25-31.

PMID:8012297
Abstract

In 8 healthy men exposed within a year to systematic +Gz accelerations with cycles of 2-month work on centrifuge followed by a month rest the functional state of the red blood cells was studied repeatedly and once in 26 fighter pilots. The blood was tested for such indices as hemoglobin, reticulocyte and erythrocyte counts; the functional state of erythrocyte pool was tested using a modified method of acidic erythrograms enabling one to record kinetic parameters of hemolysis: maximum rate of hemolysis and time of its development. Intensity of loads in the cycles of centrifuging was estimated from the Barton index. It is indicated that one of the effects of systematic exposure to +Gz accelerations is an accelerated destruction of the cells with reduced resistivity a function of exposure intensity. The destructive processes induced by accelerations trigger for a short time the mechanism of compensatory activation of the red blood system. Analysis of diagrams of percentage distribution of the parameters of the erythrocyte function after centrifuge runs of various intensity, and in the pilots revealed a significant compensatory activation of the red blood system only in 25% of pilots. The criterion validity of the indices tested for the system of individual control of the adaptive processes strain in the body is discussed.

摘要

对8名在一年内接受系统性+Gz加速度作用的健康男性进行了研究,他们以两个月在离心机上工作、随后休息一个月为周期,同时对26名战斗机飞行员也进行了一次研究,反复检测他们红细胞的功能状态。检测了血液中的血红蛋白、网织红细胞和红细胞计数等指标;采用改良的酸性红细胞图方法检测红细胞池的功能状态,该方法能够记录溶血的动力学参数:最大溶血速率及其发展时间。根据巴顿指数估算离心周期中的负荷强度。结果表明,系统性暴露于+Gz加速度的影响之一是细胞破坏加速,其抵抗力降低是暴露强度的函数。加速度引起的破坏过程在短时间内触发红细胞系统的代偿性激活机制。对不同强度离心运行后以及飞行员红细胞功能参数的百分比分布图进行分析,结果显示只有25%的飞行员红细胞系统有显著的代偿性激活。讨论了所检测指标对于个体控制身体适应性过程应激系统的标准有效性。

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