Immunofluorescent and migration inhibition studies in rats with experimental myocardial infarction.

The appearance of circulating anti-heart antibodies and myocardium-bound antibodies was demonstrated after experimental myocardial infarction induced by coronary ligation or high doses of isoproterenol in rats. Rat heart homogenate and mitochondria at 500 microgram/ml protein level inhibited the migration of leucocytes obtained from rats following myocardial infarction. The immunological consequences were similar in infarctions induced by coronary ligation or isoproterenol treatment.